![]() Depression, suicidal ideation, and suicide attempts have been reported to occur with increased frequency in patients receiving interferon compounds, including Rebif. Use Rebif with caution in patients with depression, a common condition in people with multiple sclerosis. Rebif is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon beta, human albumin, or any other component of the formulation. 4įor the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. ![]() The incidence of leukopenia and elevated liver function tests observed was lower in patients receiving 22 mcg 3 times weekly. ‡ The type of adverse events reported for 22 mcg was the same as for 44 mcg and includes, most commonly, flu-like symptoms and injection-site reactions. Both doses were shown to be effective vs placebo in the treatment of patients with relapsing forms of MS. PRISMS was not designed to determine differences in efficacy between the 22 mcg and 44 mcg-dose groups. If issue does not resolve, discontinue therapy.Dose may be gradually re-escalated when issue is resolved. ![]()
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